Date of Thesis

Summer 2025

Description

Aneuploidy, which refers to the abnormal number of chromosomes within a haploid set, has a significant effect in both physical and cognitive process of development. Proper chromosome segregation during cell division is crucial to prevent aneuploidy. Chromosome segregation is affected by the alignment of chromosomes on the metaphase plate as well as the position of centromere on the chromosome. Many arthropod species have sex chromosomes that either naturally are unpaired or pair in ways that differ for the usual patterns for autosomes. Also, some arthropods possess unique centromere position on their chromosomes which directly affects chromosome segregation pattern. Evaluating the chromosome behavior during cell division in such species provides great insight into the chromosome’s segregation pattern. The two primary goals of this study are: (1) Evaluation of sex trivalent chromosome in giant shield mantis (Rhombodera megaera) and (2) Analysis of chromosome movement in meiosis and mitosis in an organism with holocentric chromosome Oncopeltus fasciatus. In this study, I investigated both systems using live-cell and fixed cells using immunofluorescence imaging to reveal the mechanisms that control and regulate chromosome alignment and segregation, to facilitate more comprehensive understanding of general principles of chromosome behavior across species.

Keywords

chromosome segregation

Access Type

Masters Thesis

Degree Type

Master of Science

Major

Biology

First Advisor

Dr. Leocadia Paliulis

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Cell Biology Commons

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