Resolved P-Metalated Nucleoside Phosphoramidites
The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.
Miller, Erica J.; Garcia, Kevin J.; Holahan, Erin C.; Ciccarelli, Rosa M.; Bergin, Rachel A.; Casino, Stephanie L.; Bogaczyk, Tyler L.; Krout, Michael R.; Findeis, Peter M.; and Stockland, Robert A.. "Resolved P-Metalated Nucleoside Phosphoramidites." Inorganic Chemistry 53, no. 24 (2014) : 12680-12682.