Resolved P-Metalated Nucleoside Phosphoramidites

Authors

Erica J. Miller, Bucknell UniversityFollow
Kevin J. Garcia, Bucknell UniversityFollow
Erin C. Holahan, Bucknell UniversityFollow
Rosa M. Ciccarelli, Bucknell UniversityFollow
Rachel A. Bergin, Bucknell UniversityFollow
Stephanie L. Casino, Bucknell UniversityFollow
Tyler L. Bogaczyk, Bucknell UniversityFollow
Michael R. Krout, Bucknell UniversityFollow
Peter M. Findeis, Bucknell UniversityFollow
Robert A. Stockland, Bucknell UniversityFollow

Publication Date

2014

Description

The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.

Journal

Inorganic Chemistry

Volume

53

Issue

24

First Page

12680

Last Page

12682

Department

Chemistry

Link to Published Version

dx.doi.org/10.1021/ic5024357

DOI

10.1021/ic5024357

Recommended Citation

Miller, Erica J.; Garcia, Kevin J.; Holahan, Erin C.; Ciccarelli, Rosa M.; Bergin, Rachel A.; Casino, Stephanie L.; Bogaczyk, Tyler L.; Krout, Michael R.; Findeis, Peter M.; and Stockland, Robert A.. "Resolved P-Metalated Nucleoside Phosphoramidites." Inorganic Chemistry (2014) : 12680-12682.