Evidence for hormonal control of heart regenerative capacity during endothermy acquisition
Publication Date
4-12-2019
Description
Tissue regenerative potential displays striking divergence across phylogeny and ontogeny, but the underlying mechanisms remain enigmatic. Loss of mammalian cardiac regenerative potential correlates with cardiomyocyte cell-cycle arrest and polyploidization as well as the development of postnatal endothermy. We reveal that diploid cardiomyocyte abundance across 41 species conforms to Kleiber’s law—the ¾-power law scaling of metabolism with bodyweight—and inversely correlates with standard metabolic rate, body temperature, and serum thyroxine level. Inactivation of thyroid hormone signaling reduces mouse cardiomyocyte polyploidization, delays cell-cycle exit, and retains cardiac regenerative potential in adults. Conversely, exogenous thyroid hormones inhibit zebrafish heart regeneration. Thus, our findings suggest that loss of heart regenerative capacity in adult mammals is triggered by increasing thyroid hormones and may be a trade-off for the acquisition of endothermy.
Journal
Science
Volume
364
Issue
6436
First Page
184
Last Page
188
Department
Biology
Second Department
Biology
Link to Published Version
DOI
10.1126/science.aar2038
Recommended Citation
Hirose, Kentaro; Payumo, Alexander Y.; Cutie, Stephen; Hoang, Alison; Zhang, Hao; Guyot, Romain; Lunn, Dominic; Bigley, Rachel B.; Yu, Hongyao; Wang, Jiajia; Smith, Megan; Gillett, Ellen; Muroy, Sandra; Schmid, Tobias; Wilson, Emily; Field, Kenneth A.; Reeder, DeeAnn; Maden, Malcom; Yartsev, Michael M.; Wolfgang, Michael J.; Grützner, Frank; Scanlan, Thomas S.; Szweda, Luke I.; Buffenstein, Rochelle; Hu, Guang; Flamant, Frederic; Olgin, Jeffrey E.; and Huang, Guo N.. "Evidence for hormonal control of heart regenerative capacity during endothermy acquisition." (2019) : 184-188.