Date of Thesis

Spring 2023


Cancer is one of the leading causes of death around the world. However, progress in the development of novel treatments has proven difficult. By adding one of the most commonly used chemotherapeutics, cisplatin, to a peptide scaffold designed to bind and inhibit a protein, our goal is to create a platinum-peptide conjugate that inhibits the growth of cancer cells in two ways by delivering both cisplatin and a short peptide inhibitor of Lysine Specific Demethylase 1 (LSD1) in a single drug. The anticipated advantages of this approach include decreasing the cytotoxicity of traditional cisplatin treatment,1 preventing the degradation of the peptide in the biological environment,2 and increasing the overall efficacy of the drug in the treatment of cancer by combining two different therapeutic approaches in a single drug. In this thesis, I discuss the expression and purification of the target protein, LSD1, in addition to the synthetic steps undertaken to link the cisplatin molecule to the peptide backbone.


Biochemistry, Peptides, Platinum therapeutics

Access Type

Honors Thesis (Bucknell Access Only)

Degree Type

Bachelor of Science


Cell Biology/Biochemistry

First Advisor

Sarah J. Smith

Available for download on Sunday, May 10, 2026