Date of Thesis
human cytomegalovirus, HCMV, virology, tegument, pp65, pp71, pp150, pp28, transfection, confocal microscopy, molecular biology
To determine the subcellular localization of the tegument proteins pp65, pp71, pp150, and pp28 as fusions to one of several fluorescent proteins. Since these tegument proteins play pivotal roles in several stages of the viral life cycle, knowledge of where and the mechanism of how these proteins localize upon release could result in a better understanding of their function during a lytic infection as well as assist in the development of an effective, novel antiviral treatment.
Tomtishen, John Paul III, "Tegument Protein Subcellular Localization of Human Cytomegalovirus" (2011). Honors Theses. 23.