Date of Thesis

12-14-2016

Thesis Type

Masters Thesis (Bucknell Access Only)

Degree Type

Master of Science

Department

Biology

First Advisor

Leocadia V. Paliulis

Abstract

Aneuploidy is poorly tolerated by cells and can have catastrophic consequences, including infertility and death, for offspring. Normally, chromosomes partner during meiosis in such a way as to guarantee their correct segregation into daughter cells and prevent aneuploidy. If their connections to one another and to the spindle network are improperly regulated, however, cells can have missing or extra chromosomes as a result. In some species, nonhomologous chromosomes that have no pairing partners in meiosis can have coordinated movements and behaviors that result in their correct delivery into daughter cells. We are interested in how chromosome movements are coordinated to ensure correct chromosome segregation into daughter cells during meiosis. To study this, we look at these "strange" cases of chromosome segregation, as they could reveal a lot about the coordination of chromosome movements in all species.

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