Date of Thesis
2011
Description
Drug release from a fluid-contacting biomaterial is simulated using a microfluidic device with channels defined by solute-loaded hydrogel. In order to mimic a drug delivery device, a solution of poly(ethylene glycol) diacrylate (PEG-DA), solute, and photoinitiator is cured inside a microfluidic device with a channel through the center ofthe hydrogel. As water is pumped through the channel, solute diffuses out of the hydrogel and into the water. Channel sizes within the devices range from 300 µm to 1000 µm to simulate vessels within the body. The properties of the PEG hydrogel were characterizedby the extent of crosslinking, the swelling ratio, and the mesh size of the gel. The structure of the hydrogel was related to the UV exposure dosage and the initial water and solute content in the PEG-DA solution.
Keywords
Hydrogels, Poly(ethylene glycol) diacrylate, Elution, Diffusion, Microfluidics
Access Type
Masters Thesis
Degree Type
Master of Science in Chemical Engineering
Major
Chemical Engineering
First Advisor
Erin Jablonski
Recommended Citation
Evans, Stephanie, "Modeling Small Molecule Elution From a Hydrogel using a Microfluidic Technique" (2011). Master’s Theses. 1.
https://digitalcommons.bucknell.edu/masters_theses/1