Social cognition, face processing, and oxytocin receptor single nucleotide polymorphisms in typically developing children
Developmental Cognitive Neuroscience
Recent research has provided evidence of a link between behavioral measures of social cognition (SC) and neural and genetic correlates. Differences in face processing and variations in the oxytocin receptor (OXTR) gene have been associated with SC deficits and autism spectrum disorder (ASD) traits. Much work has examined the qualitative differences between those with ASD and typically developing (TD) individuals, but very little has been done to quantify the natural variation in ASD-like traits in the typical population. The present study examines this variation in TD children using a multidimensional perspective involving behavior assessment, neural electroencephalogram (EEG) testing, and OXTR genotyping. Children completed a series of neurocognitive assessments, provided saliva samples for sequencing, and completed a face processing task while connected to an EEG. No clear pattern emerged for EEG covariates or genotypes for individual OXTR single nucleotide polymorphisms (SNPs). However, SNPs rs2254298 and rs53576 consistently interacted such thatthe AG/GG allele combination ofthese SNPs was associated with poorer performance on neurocognitive measures. These results suggest that neither SNP in isolation is risk-conferring, but rather thatthe combination of rs2254298(A/G) and rs53576(G/G) confers a deleterious effect on SC across several neurocognitive measures.
Slane, Mylissa M.; Lusk, Laina; Boomer, K B.; Harre, Abby E.; King, Margaret K.; and Evans, David W.. "Social cognition, face processing, and oxytocin receptor single nucleotide polymorphisms in typically developing children." Developmental Cognitive Neuroscience 9, (2014) : 160-171.
This document is currently not available here.