Title

Resolved P-Metalated Nucleoside Phosphoramidites

Publication Date

2014

Journal

Inorganic Chemistry

Volume

53

Issue

24

First Page

12680

Last Page

12682

Abstract

The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.

DOI

10.1021/ic5024357

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