Title

Reply to Davis: Nitric Oxide Regulates Lymphatic Contractions

Publication Date

1-2016

Journal

Proceedings of the National Academy of Sciences

Volume

113

Issue

2

First Page

E106

Last Page

E106

Abstract

We appreciate the opportunity to respond to Michael J. Davis’s Letter (1) regarding our paper “Mechanobiological Oscillators Control Lymph Flow” (2).

Our model was developed to study phasic contractions and the dynamics of NO and calcium rather than the control of basal tone. Many factors—in addition to NO—affect lymphatic baseline diameter, including inflammatory cytokines and hormones, and the mechanical properties of the surrounding tissue. On the other hand, there are few mechanisms that operate at the short timescales required for the phasic contractions. Our simulations show that NO and Ca2+ are sufficient to drive these phasic contractions and that mechanobiological regulation of their levels provides intrinsic feedback …

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